BIBR1532, a Selective Telomerase Inhibitor, Enhances Radiosensitivity of Non-Small Cell Lung Cancer Through Increasing Telomere Dysfunction and ATM/CHK1 Inhibition
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چکیده
منابع مشابه
Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549)
BACKGROUND F1Fo-ATP synthase (F1Fo-ATPase) is a reversibly rotary molecular machine whose dual functions of synthesizing or hydrolyzing ATP switch upon the condition of cell physiology. The robust ATP-hydrolyzing activity occurs in ischemia for maintaining the transmembrane proton motive force of mitochondria inner membrane, but the effect of F1Fo-ATPase on X-ray response of non-small-cell lung...
متن کاملSelective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532.
Telomerase represents an attractive target for a mechanism-based therapeutic approach because its activation has been associated with unlimited proliferation in most cancer cells. Recently, a nonnucleosidic small molecule inhibitor, BIBR1532 (2-[(E)-3-naphtalen-2-yl-but-2-enoylamino]-benzoic acid), has been identified that is highly selective for inhibition of telomerase, resulting in delayed g...
متن کاملTelomere length and telomerase activity in non-small cell lung cancer prognosis: clinical usefulness of a specific telomere status
BACKGROUND Considering previous data and the need to incorporate new biomarkers for the prognosis of solid tumours into the clinic, our aim in this work consists of evaluating the potential clinical use of telomeres and telomerase in non-small cell lung cancer (NSCLC). METHODS Telomere status was established by determination of telomere length using the Terminal Restriction Fragment length me...
متن کاملAZT-mediated inhibition of telomerase activity suppresses pancreatic cancer cell proliferation and enhances their radiosensitivity
Objective: To investigate the effects of AZT-mediated inhibition of telomerase activity on the proliferation, apoptosis and radiosensitivity of panc1 cells, and the growth of pancreatic tumor in vivo. Methods: panc1 cells were divided into four groups: A, control group; B, 0.4 mmol/L AZT; C, 0.6 mmol/L AZT; and D, 0.8 mmol/L AZT group. Cell proliferation was assessed by MTT assay. Cell apoptosi...
متن کاملTelomerase activity in non-small cell lung cancer
INTRODUCTION High telomerase activity has been detected in the majority of malignant neoplasms including lung cancer. The purpose of the study was to attempt to use telomerase activity as a prognostic factor in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS Telomerase activity was analyzed in 47 tissue specimens taken from patients with NSCLC. The control group consist...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2019
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2019.08.009